تخطيطات العمائر الدينية لعائلة کوبرولو (1067- 1114هـ/1656- 1702م) بمدينة استانبول وسافران بولو وحکيم خانه
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چکیده
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Op-brai140030 1051..1067
Diabetes mellitus renders both widespread and localized irreversible damage to peripheral axons while imposing critical limitations on their ability to regenerate. A major failure of regenerative capacity thereby imposes a ‘double hit’ in diabetic patients who frequently develop focal neuropathies such as carpal tunnel syndrome in addition to generalized diffuse polyneuropathy. The mechanisms o...
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Atorvastatin is eliminated by CYP3A4 which follows carrier-mediated uptake into hepatocytes by OATP1B1, OATP1B3, and OATP2B1. Multiple clinical studies demonstrated that OATP inhibition by rifampin had a greater impact on atorvastatin systemic concentration than itraconazole-mediated CYP3A4 inhibition. If it is assumed that the blood and hepatocyte compartments are differentiated by the concent...
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X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum Juliane Najm1,13, Denise Horn2,13, Isabella Wimplinger1, Jeffrey A Golden3, Victor V Chizhikov4, Jyotsna Sudi4, Susan L Christian4, Reinhard Ullmann5, Alma Kuechler6, Carola A Haas7, Armin Flubacher7, Lawrence R Charnas8, Gökhan Uyanik9, Ulrich Frank10, Eva Klopocki2, William B Dobyns4,11,12 &...
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Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be effective in axonal protection. Sodium channel blocking agents can provide effective protection of axons in the white matter in experimental models of multiple sclerosis, but the mechanism of action (directly on axons or indirectly via immun...
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ژورنال
عنوان ژورنال: مجلة الإتحاد العام للآثاريين العرب
سال: 2021
ISSN: 2536-9830
DOI: 10.21608/jguaa.2021.67178.1172